Targeting UDP-Glycosyltransferase, Glucosamine-6-Phosphate Synthase and Chitin Synthase by Using Bioactive 1,8 Cineole for “Aspergillosis” Fungal Disease Mutilating COVID-19 Patients: Insights from Molecular Docking, Pharmacokinetics and In-vitro Studies

SARS-CoV-2 (COVID-19)-associated co-infections like “Aspergillosis”, has recently baffled the world. Due to its key role in cell wall synthesis, present study UDP-glycosyltransferase, glucosamine-6-phosphate synthase and chitin have been chosen as appropriate targets for molecular docking. The objective of was docking eucalyptus essential oil component 1,8 cineole against enzymes followed by vitro validation. For docking, patch-dock web based online tool used. Ligand–Protein 2D 3D Interactions were also studied. Drug likeliness, toxicity profile cancer line Molecular results indicated that form hydrogen bonding hydrophobic interactions with enzymes. depicted drug likeliness showing compliance LIPINSKY rule, sufficient level bioactivity thus signifying a potent anti-fungal drug.